Mild and Selective Deprotection of tert-Butyl(dimethyl)silyl Ethers with Catalytic Amounts of Sodium Tetrachloroaurate(III) Dihydrate
نویسندگان
چکیده
منابع مشابه
Mild, selective deprotection of PMB ethers with triflic acid/1,3-dimethoxybenzene
An efficient method for the cleavage of the p-methoxybenzyl protecting group of several alcohols in the presence of 0.5 equiv of trifluoromethanesulfonic acid and 1,3-dimethoxybenzene in dichloromethane at room temperature is described. 2011 Elsevier Ltd. All rights reserved. O OAc Me HO PMBO O-allyl 1 O AcO AcO NPhth AcO O NH CCl3 2 O OAc Me O O AcO AcO AcO
متن کاملOxidative photoredox catalysis: mild and selective deprotection of PMB ethers mediated by visible light.
Herein we report an advancement in the application of visible light photoredox catalysts in the oxidation of electron-rich arenes resulting in the selective deprotection of para-methoxybenzyl (PMB) ethers. This method is highlighted by excellent functional group tolerance, protecting group orthogonality, mild reaction conditions and avoidance of stoichiometric redox byproducts.
متن کاملDeprotection of t-Butyldimethylsiloxy (TBDMS) Protecting Group with Catalytic Copper (II) Chloride Dihydrate
The protection of functional group is unavoidable in multi-step organic synthesis. Along with tetrahydropyranyl (THP) ethers, t-butyldimethylsilyl (TBDMS) ethers have been widely used for protecting hydroxyl groups. TBDMS ether is more stable to hydrolysis than trimethylsilyl ether, but is still readily cleaved by a variety of selective conditions. The deprotection of TBDMS is usually under mil...
متن کاملSelective conversion of alcohols and phenols to tetrahydropyranyl ethers catalyzed with N-chlorosaccharin under mild and solvent-free conditions
An efficient method is described for the mild and rapid tetrahydropyranylation of alcohols and phenols using a catalytic amount of N-chlorosaccharin (1 mol %) and 3, 4-dihydro-2H-pyran under solvent-free condition at room temperature. Benzylic alcohols and phenols containing electron withdrawing or donating groups in various positions of phenyl ring, cinamyl alcohol, primary, ...
متن کاملSelective conversion of alcohols and phenols to tetrahydropyranyl ethers catalyzed with N-chlorosaccharin under mild and solvent-free conditions
An efficient method is described for the mild and rapid tetrahydropyranylation of alcohols and phenols using a catalytic amount of N-chlorosaccharin (1 mol %) and 3, 4-dihydro-2H-pyran under solvent-free condition at room temperature. Benzylic alcohols and phenols containing electron withdrawing or donating groups in various positions of phenyl ring, cinamyl alcohol, primary, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Synthesis
سال: 2014
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-0034-1379032